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Edit:2021.10.27<markdown>

Immunology, Ideology, Power

In 2005, experiments showed that injecting

the spike protein from a corona virus caused

lungs to fail (Kuba, et al.), and that antibodies

formed to the spike protein damaged the lungs

(Lin, et al.). For several decades, it has been

common knowledge that autoimmune disease

(such as “rheumatic fever”) could result from

the cross reaction of antibodies with microbial

antigens and antigens on the person’s tissues.

Recent studies are confirming the risk of

autoimmune disease from antibodies to the

covid spike protein. One cross-reaction with

the spike protein is the lung surfactant protein

(Vojdania and Kharraian, 2020; Talotta, 2021).

Cross-reactive antibodies and autoimmune

processes are also involved in cancer and

infertility.

With both the spike protein and the

antibodies to it producing such deadly effects,

using it in a vaccine to protect against the

corona virus would have seemed crazy to

anyone following immunological and virologi-

cal research after 2005, and the thought of

implanting a nucleic acid to cause the body to

produce the spike protein would have seemed

like criminal insanity at that time. Just 12 years

later, big corporations and their government

supporters found it convenient to forget the

recent science. For example, in 2017 the chief

medical officer of the Moderna corporation

gave a talk about what a nifty and simple idea

if would be to cause the body to produce its

own vaccine. Describing the process, he said

“So, here’s all the biology you need to know

in 30 seconds.” For the corporations and the

public health officials, that’s all the biology

they want to know, and all they want the

public to know.

In the immunity that results from interac-

tions with pathogenic organisms, and in the

immunity produced by a traditional vaccine

made from killed or weakened pathogens, the

body forms antibodies to many parts of the

potentially harmful organism. The result is

that we accumulate a great variety of antibod-

ies to multiple pathogens, and in the case of

corona viruses, children accumulate additional

immunity each time they have a cold. This

means that almost all children and adults are

immune to a great variety of corona viruses.

At birth, there are natural antibodies, that

developed along with the differentiation of

tissues. Naturally, they don’t inactivate the

body’s own tissues; they persist through life,

but decrease with aging, increasing the

susceptibility to infections and to loss of

normal functions (Palma, et al., 2018). They

apparently serve to protect tissues, recognizing

and eliminating deviations from normal

(Britschgi, et al., 2009). Their existence has

been generally accepted only in recent

Ray Peat's Newsletter

. . . it is easier to bamboozle than to debamboozle. Norman Angell Copyright 2021 Raymond Peat P.O. Box 5764 Eugene OR 97405 September 2021 Not for republication without written permission.* — Page 2 decades; their existence creates difficulties for the dominant theory of immunity. With natural antibodies, the issue of cross- reactive antibodies and autoimmunity doesn’t exist, but when the specialized adaptive antibodies are produced, cross-reactivity is always a problem—other organisms vary in their tissue antigens, and antibodies binding to those will have varying degrees of cross- reactive affinity for our own tissues. For example, the lactobacilli that thrive in women during their fertile years have some antigens that resemble human connective tissues, and it’s possible that they are a factor in diseases such as lupus and rheumatoid arthritis that are prevalent in women especially during those years. Any infection or vaccination, especially when there’s an excess of estrogen or a deficiency of antiinflammatory factors, can permanently damage your health. The first two people in the U.S. reported to have died from “covid,” at the end of February, 2020 were in their 80s and 90s, in an extended care home in the Tacoma, Washing- ton area, and within a few days a third death was also said to have been caused by covid; their deaths were attributed to covid on the basis of a PCR test that, despite not having been validated as tests normally are, had just been authorized for use under a newly adopted Emergency Use Authorization. Secretary of Health and Human Services, Alex Azar, had declared a Public Health Emergency on January 31, 2020. The fact that the WHO recommended, and the CDC ordered, the operation of the test at 40 to 45 cycles, known to produce mostly false positive results was widely noticed: as testing increased nationally beginning in March, the incidence of “cases of covid” increased at the same rate as the testing. The “test epidemic” served to create an eager- ness to get the inoculation. Exactly a year after the WHO had begun promoting the testing method of Christian Drosten, with instructions to misuse it, the inoculation campaign was underway, and the WHO changed its instruc- tions, reducing the number of cycles—with the obvious intention of creating an impres- sion that the inoculations were lowering the rate of infection, as the number of false positive results was immediately reduced. In the late 19th century Paul Ehrlich, working with the German dye industry, noticed that different bacteria and tissues varied in their affinities for coal tar dyes. He reasoned that the ability of some dyes to kill certain pathogenic organisms was analogous to specific immunity, such as demonstrated by vaccination. He extended his dye-binding theory to the use of arsphenamine (Salvarsan, Compound 606) to treat trypanosomiasis and syphilis. His Nobel lecture (1908) was a detailed description of a theory in which tissue and chemical side chains were similarly responsible for the therapeutic effects of drugs and the protective effects of antibodies. His theory made the “magic bullet” idea of drug therapy popular, reinforcing the idea that each disease has its specific drug remedy. The power of the drug industry was able to make that idea central to medicine, and it shaped thinking about vaccines for the next century. Metchnikov’s 1908 Nobel lecture wasn’t just about phagocytosis, it was an alternative view of immunity as a pervasive multi-level process, involving learning and tissue mainte- nance as well as specific elimination of patho- gens. It was either ignored or disparaged by medical researchers until the end of the 20th century. He said that at the present time, he knew of only one substance that could assist the innate immune system, and that was quinine. Recent studies relating to a single kind of cell sensor, the Toll-Like Receptors (TLRs), have found that quinine reduces their activation of cytokines and antibodies. Angio- tensin, the covid virus (Sarius and Perlman, 2021), endotoxin, estrogen, and ionizing 2 — Page 3 radiation have opposite effects, activating TLRs and increasing cytokine and antibody production. In Metchnikov’s time, chloroquine and hydroxychloroquine hadn’t been synthesized yet. Those drugs weren’t introduced because they were in some way superior to quinine. In the 1930s, Germany and the US wanted new drugs to treat malaria, to get around Dutch control of the world quinine supply, and produced several synthetic variations of quinine, including chloroquine. In 1950, hydroxychloroquine was produced to avoid the retinal toxicity of chloroquine. Recently, because of reports that hydroxychloroquine could be helpful for treating the corona virus infection, some researchers compared the effects in vitro of quinine and the two synthet- ics on human cells (Grosse, et al., 2021). They found that natural quinine, like the synthetics, effectively blocked the infection of human cells by the corona virus, but was safer. The more toxic chloroquine had previously been found to have antiviral effect against SARS coronavirus (Vincent, et al., 2005). Metchnikov’s developmental, multilevel, cellular view of immunity was incompatible with “modern medicine.” The American Medical Association was founded in 1847 to promote “scientific” allopathic medicine, and to suppress the practice of homeopathy, empirical medicine, herbalism, etc. It opposed the use of “crude” herbal preparations, and considered it necessary to find a pure chemical substance to specifically treat each condition, such as a microbial infection, a parasite, or, later, a genetic defect. This theory of medicine is a perfect match for the pharmaceutical industry, and for Ehrlich’s analogy of “magic bullet” chemotherapy to the function of antibodies. It was only a little more than 20 years ago that Jamie Cunliffe’s “morphostasis” and “damage theory” and Polly Matzinger’s “danger theory” broke away from the dominant antibody theory of immunity, which was based on Macfarlane Burnet’s mechanis- tic, neodarwinian “clonal deletion” theory. These new theories were, in effect, extensions of Metchnikov’s developmental approach in which immunity is a process of generating and maintaining the organism. When a cell is damaged, it releases internal components including DNA, RNA, and ATP, and these are recognized by cells that promote repair of the damage, under the guidance of systemic inter- actions. Unfamiliar antigens will be eliminated along with the damaged tissue, by a combina- tion of many factors, from phagocytes to antibodies. A few people had been recognizing the failure of the clonal deletion theory for a long time. At an international meeting of immunologists in 1969 at the University of Oregon, a young teacher had demonstrated that the deleted clones could be restored, giving the original repertoire of antibodies, if the immune cells were simply cultured at a higher density than Burnet and Nossal had used, allowing the cells to interact with each other, forming a network that was able to detect, and repair, the deletions. Although his lecture was attended by only a few people, and the main speakers acted as though it hadn’t happened, Niels Jerne appar- ently noticed it, because he later presented an alternative to clonal deletion based on his idea of an “idiotype-antiidiotype network” (Jerne, 1974). By itself, it wasn’t an adequate theory, but it moved in the right direction. The damage and danger theories have provided a way to discard the various Nobel Prize winning theories of antibodies and their functions, and to begin seeing immunity and resistance as holistic processes of the organism. The nature of protective reactions has been obscured by thinking in terms of “the immune system,” as something distinct from metabolic and adaptive processes. The various 3 — Page 4 “-phylaxes,” starting with skeptophylaxis (lightning or quick protection), have made it clear that the endocrine system and metabolic systems are deeply involved in the adaptive protections. Although mast cells and basophils are usually the main sources of histamine, experi- ments have shown that under the most extreme conditions, all of the cells studied produced histamine. Energy deprivation activates the formation of histamine, which activates many “immune” functions, including increasing the TLRs, and production of cytokines and antibodies. Histamine should probably be thought of as one of the signals of danger or damage. It seems to correspond to the catabolic phase of an infection. Although inflammation can occur without infection, its presence is generally thought to indicate infection. The corona virus infections inactivate the ACE2 enzyme, whose functions include destroying angiotensin II, a basic promoter of inflammation, so, more than other kinds of infection, it is a disease of inflamma- tion. Since inflammation activates the clotting system, it is a disease of inflammation and coagulation. Before the WHO declared the pandemic, China was treating covid infections with antiinflammatories and anticoagulants. Outside of China, governments have ordered doctors not to treat early cases of covid, until their symptoms were serious enough to require hospitalization and oxygen treatment. On October 22, 2020, the FDA approved the use of remdesivir in covid patients, but remdesivir is neither antiinflammatory nor anticoagulant; inflammation is one of its side effects. Histamine helps to rouse the immune functions, and promotes inflammation and coagulation. In a prolonged excess, it tends to calcify soft tissues, reducing their functions. Like serotonin, it activates carbonic anhydrase, and is activated by estrogen and a reducing environment. While histamine is a basic organizing factor in immunity, its effects have to be blocked for completion of the immune processes. Increased oxidative metabolism lowers histamine and inflammation systemi- cally, for example by lowering the ratio of estrogen to progesterone. Although anaphylaxis is usually thought of as something separate from the immune response, I think it just represents a quick entry into the high-histamine state, because of low energy reserves and slow mobilization of the hormones of homeostasis. In the 1960s, V. W. Adamkiewicz showed that reducing blood glucose with insulin greatly intensified aller- gic reactions, while increasing blood glucose prevented deadly anaphylaxis, but weakened resistance to infection. Energy metabolism governs the effectiveness of the immune process, including the avoidance of autoim- munity (Gaber, et al., 2017). Metabolic energy is involved in every aspect of the covid infection, but that has been denied or ignored because of a traditional, ideological understanding of immunity. Denial of obvious facts isn’t a rare thing in the history of science, but the recent world-wide reactions to the corona virus epidemics, including crimi- nalization of the traditional medical practice of treating symptoms, are unique and completely outside any scientific, medical, or legal standards. Moderna had been working on RNA vaccines for years when the “novel” corona virus was identified, and they had been testing it as a vaccine for corona virus in mice, so when they received the genetic code by telephone from China, it took them only a few hours to produce the vaccine. As they rushed through the preliminary trials, it supposedly didn’t occur to anyone that the vaccine might spread throughout the body, or that it would infect the lining of blood vessels with the spike protein, or that the infected endothelial cells would cause systemic clotting and inflammation, or that if the spike protein 4 — Page 5 reached the lungs it would severely damage them, or that anti-spike antibodies would be toxic to the lungs, or that anti-antispike antibodies would contain an antigen similar to the spike antigen. They, like Pfizer, were undoubtedly aware of the risks of the shedding phenomenon. These facts would imply either that no one in the vaccine business had studied physiology or immunology with any attention, or that their plan—to inoculate everyone in the world with a highly toxic genetic material—wasn’t intended to improve public health. REFERENCES Can Med Assoc J. 1963 April 13; 88(15): 806–811. Glycemia and Immune Responses. V. W. Adamkiewicz. The intensity of experimental and clinical immune responses was correlated with the degree of glycemia of the reacting subject. Hyperglyce- mias resulting from overdosage with sugars, corti- sol, adrenaline, or from diabetes inhibit the anaphylactoid reactions; anaphylaxis, and the tuberculin reaction; but potentiate infections. Hypoglycemias resulting from fasting, insulin and adrenalectomy potentiate the anaphylactoid reactions, anaphylaxis, and the tuberculin reaction; but inhibit infections. The hypothesis is proposed that hyperglycemia inhibits certain antigen- antibody combinations; this results in an inhibition of hypersensitivity, but an aggravation of infection. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12145-50. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. M Britschgi, C E Olin, H T Johns, Y Takeda-Uchimura, M C LeMieux, K Rufibach, J Rajadas, H Zhang, B Tomooka, W H Robinson, C M Clark, A M Fagan, D R Galasko, D M Holtzman, M Jutel, J A Kaye, C A Lemere, J Leszek, G Li, E R Peskind, J F Quinn, J A Yesavage, J A Ghiso, T Wyss-Coray. Clin Exp Immunol. 2005 Sep;141(3):500-8. Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity. Y S Lin, C F Lin, Y T Fang, Y M Kuo, P C Liao, T M Yeh, K Y Hwa, C C K Shieh, J H Yen, H J Wang, I J Su, H Y Lei. Nature Reviews Rheumatology volume 13, pages 267–279 (2017). Metabolic regulation of nflammation. Timo Gaber, Cindy Strehl &amp; Frank Buttgereit. Ann Immunol (Inst Pasteur) 125 C: 373. (1974). Towards a network theory of the immune system. Jerne NK. Nat Med. 2005 Aug;11(8):875-9. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Keiji Kuba, Yumiko Imai, Shuan Rao, Hong Gao, Feng Guo, Bin Guan, Yi Huan, Peng Yang, Yanli Zhang, Wei Deng, Linlin Bao, Binlin Zhang, Guang Liu, Zhong Wang, Mark Chappell, Yanxin Liu, Dexian Zheng, Andreas Leibbrandt, Teiji Wada, Arthur S Slutsky, Depei Liu, Chuan Qin, Chengyu Jiang, Josef M Penninger Annu Rev Immunol. 1994;12:991-1045. Tolerance, danger, and the extended family. P Matzinger. For many years immunologists have been well served by the viewpoint that the immune system's primary goal is to discriminate between self and non-self. I believe that it is time to change viewpoints and, in this essay, I discuss the possi- bility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues. Cent Eur J Immunol. 2018; 43(4): 466–475. Natural antibodies–-facts known and unknown. Joanna Palma, Beata Tokarz-Deptuła, Jakub Deptuła, and Wiesław Deptuła. J Theor Biol. 2015 Jun 21; 375: 71–76. Molecular Mimicry and Clonal Deletion: A Fresh Look. Noel R. Rose. Nat Immunol 22, 801–802 (2021). SARS- CoV-2 takes its Toll. Sariol, A., Perlman, S. Immunology. 2004 Oct; 113(2): 224–233. Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram- negative bacterial cell wall components. Jaya 5 — Page 6 Talreja, Mohammad H Kabir, Michael B Filla, Daniel J Stechschulte, and Kottarappat N Dileepan Clin Immunol. 2021 Mar; 224: 108665. Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases.” Rossella Talotta Virol J. 2005 Aug 22;2:69. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Martin J Vincent, Eric Bergeron, Suzanne Benjannet, Bobbie R Erickson, Pierre E Rollin, Thomas G Ksiazek, Nabil G Seidah, Stuart T Nichol. Clin Immunol. 2020 Aug; 217: 108480. Poten- tial antigenic cross-reactivity between SARS- CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Aristo Vojdania, and Datis Kharrazian. Videos, Virus, Vaccines Steve Kirsch: https://trialsitenews.com/silicon‐valley‐drug‐developm ent‐philanthropist‐tours‐vaers‐comparing‐influenzas‐c ovid‐19‐vaccine‐data/ https://trialsitenews.com/are‐the‐covid‐19‐vaccines‐sa fe‐and‐effective/ Mike Yeadon: https://www.brighteon.com/a92e53c2‐8c35‐498a‐ba7 4‐c6ab652dcffa https://www.bitchute.com/video/9enapGHu7UmI/ Peter McCullough: https://www.youtube.com/watch?v=QAHi3lX3oGM https://rumble.com/vk5jd0‐dr.‐peter‐mccullough‐urge nt‐warning‐about‐poisonous‐jabs‐an‐agonizing‐situa.ht ml Dolores Cahill: https://www.bitchute.com/video/M7tOFVckPlCT/ Robert Malone interview with Jimmy Dore: https://www.bitchute.com/video/HzNd9t3ipfzV/ Fleming, Novavax, accountability: Https://www.bitchute.com/video/LzTeejWo9rTr/ Reiner Fuellmich, July 17, 2021: https://www.bitchute.com/video/XHEvvvveUVJE/ David Knight and Lee Merritt: https://www.bitchute.com/video/wBXKh4QXEGtu/ Lee Merritt: (D-dimer 60%) https://www.brighteon.com/eb1b58c0‐d62f‐4229‐90 98‐5fd861118053 Sucharit Bhakdi: https://factcheckvaccine.com/2021/07/an‐urgent‐me ssage‐from‐professor‐dr‐sucharit‐bhakdi‐july‐9‐2021/ https://www.brighteon.com/681b0af1‐f34f‐4d3b‐849 a‐40caf675b7d1 Bhakdi Sept 3: https://www.bitchute.com/video/ry6p1Glnp760/ Mike Adams interviewing Dr. David Martin: https://www.bitchute.com/video/ZxGqUdGddRPo/ https://www.brighteon.com/309412a4‐65e5‐4bd6‐a7 c9‐52805b5a6b93 Funeral director: https://rumble.com/vmlz42‐funeral‐director‐john‐olo oney‐blows‐the‐whistle‐on‐covid.html Charles Hoffe, a Canadian doctor: https://www.bitchute.com/video/ijiltpFuhwyk/ Ryan Cole: https://www.bitchute.com/video/I5IPjw0POAlF/ Ethics Professor: https://rumble.com/vm8ie1‐ethics‐professor‐gives‐he artbreaking‐final‐lesson‐on‐refusing‐vaccine‐befor.ht ml </markdown> Edit:2021.10.27 <markdown> </markdown> 讨论列表 AKP讨论 查看原帖及回帖