衰老和CO2的保护作用


Yandell Henderson:二氧化碳

血红蛋白是血液运输氧气的手段。

血碱作为二氧化碳的载体。

D:2021.08.30>

REFERENCES
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E621-7. Uncoupling protein-2 regulates lifespan in mice. Andrews ZB, Horvath TL.
Fiziol Zh SSSR 1978 Oct;64(10):1456-62. [Role of CO2 fixation in increasing the body's resistance to acute hypoxia]. Baev VI, Vasil'ev VV, Nikolaeva EN. In rats, the phenomenon of considerable increase in resistance to acute hypoxia observed after 2-hour stay under conditions of gradually increasing concentration of CO2, decreasing concentration of O2, and external cooling at 2–3 degrees seems to be based mainly on changes in concentration of CO2 (ACCORDINGLY, PCO2 and other forms of CO2 in the blood). The high resistance to acute hypoxia develops as well after subcutaneous or i.v. administration of 1.0 ml of water solution (169.2 mg/200 g) NaHCO2, (NH4)2SO4, MgSO4, MnSO4, and ZnSO4 (in proportion: 35 : 5 : 2 : 0.15 : 0.15, resp.) or after 1-hour effect of increased hypercapnia and hypoxia without cooling.
Fiziol Zh Im I M Sechenova 1995 Feb;81(2):47-52. [The unknown physiological role of carbon dioxide]. Baev VI, Vasil'eva IV, L'vov SN, Shugalei IV [The data suggests that carbon dioxide is a natural element of the organism antioxidant defence system. ion poisoning].
Stroke. 1996 Sep;27(9):1634-9; discussion 1639-40. Differential effects of short-term hypoxia and hypercapnia on N-methyl-D-aspartate-induced cerebral vasodilatation in piglets. Bari F, Errico RA, Louis TM, Busija DW.
Vojnosanit Pregl. 1996 Jul-Aug;53(4):261-74. [Carbon dioxide inhibits the generation of active forms of oxygen in human and animal cells and the significance of the phenomenon in biology and medicine] [Article in Serbian] Boljevic S, Kogan AH, Gracev SV, Jelisejeva SV, Daniljak IG.
J Exp Biol. 1979 Oct;82:357-65. Acid-base relationships in the blood of the toad, Bufo marinus. III. The effects of burrowing. Boutilier RG, Randall DJ, Shelton G, Toews DP.
Acta Neurobiol Exp (Wars). 2007;67(2):197-206. Role of hypercapnia in brain oxygenation in sleep-disordered breathing. Brzecka A. Adaptive mechanisms may diminish the detrimental effects of recurrent nocturnal hypoxia in obstructive sleep apnea (OSA). The potential role of elevated carbon dioxide (CO2) in improving brain oxygenation in the patients with severe OSA syndrome is discussed. CO2 increases oxygen uptake by its influence on the regulation of alveolar ventilation and ventilation-perfusion matching, facilitates oxygen delivery to the tissues by changing the affinity of oxygen to hemoglobin, and increases cerebral blood flow by effects on arterial blood pressure and on cerebral vessels. Recent clinical studies show improved brain oxygenation when hypoxia is combined with hypercapnia. Anti-inflammatory and protective against organ injury properties of CO2 may also have therapeutic importance. These biological effects of hypercapnia may improve brain oxygenation under hypoxic conditions. This may be especially important in patients with severe OSA syndrome.
Ageing Res Rev. 2009 Oct;8(4):268-76. Epub 2009 Apr 1. The role of epigenetics in aging and age-related diseases. Calvanese V, Lara E, Kahn A, Fraga MF.
Rev Esp Geriatr Gerontol. 2009 Jul-Aug;44(4):194-9. Epub 2009 Jul 3. [Effect of restricting amino acids except methionine on mitochondrial oxidative stress.] [Article in Spanish] Caro P, Gómez J, Sánchez I, López-Torres M, Barja G.
Cell Metab. 2007 Jan;5(1):21-33. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, Horvath TL, Gao XB, Diano S.
Ter Arkh. 1995;67(3):23-6. [Changes in the sensitivity of leukocytes to the inhibiting effect of CO2 on their generation of active forms of oxygen in bronchial asthma patients] Daniliak IG, Kogan AKh, Sumarokov AV, Bolevich S.
Cell Metab. 2007 Dec;6(6):497-505. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Gates AC, Bernal-Mizrachi C, Chinault SL, Feng C, Schneider JG, Coleman T, Malone JP, Townsend RR, Chakravarthy MV, Semenkovich CF.
Endocr Pract. 2009 Jun 2:1-13. Fibrotic Appearance of Lungs in Severe Hypothyroidism is Reversible with Thyroxine Replacement. George JT, Thow JC, Rodger KA, Mannion R, Jayagopal V.
J Bioenerg Biomembr. 2009 Jun;41(3):309-21. Epub 2009 Jul 25. Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart. Gomez J, Caro P, Sanchez I, Naudi A, Jove M, Portero-Otin M, Lopez-Torres M, Pamplona R, Barja G.
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7612-7. Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. Hyder F, Chase JR, Behar KL, Mason GF, Siddeek M, Rothman DL, Shulman RG.
Can J Neurol Sci. 1979 May;6(2):105-12. The effects of partial chronic denervation on forearm metabolism. Karpati G, Klassen G, Tanser P.
Biull Eksp Biol Med. 1994 Oct;118(10):395-8. [CO2–a natural inhibitor of active oxygen form generation by phagocytes] Kogan AKh, Manuilov BM, Grachev SV, Bolevich S, Tsypin AB, Daniliak IG.
Izv Akad Nauk Ser Biol. 1997 Mar-Apr;(2):204-17. [Carbon dioxide–a universal inhibitor of the generation of active oxygen forms by cells (deciphering one enigma of evolution)] Kogan AKh, Grachev SV, Eliseeva SV, Bolevich S.
Vopr Med Khim. 1996 Jul-Sep;42(3):193-202. [Ability of carbon dioxide to inhibit generation of superoxide anion radical in cells and its biomedical role] Kogan AKh, Grachev SV, Eliseeva SV, Bolevich S.
Dokl Akad Nauk. 1996 May;348(3):413-6. [New evidence for the inhibitory action of CO2 on generation of superoxide anion radicals by phagocytes in various tissues. (Mechanism of bio- and eco-effects of CO2)] Kogan AKh, Grachev SV, Bolevich S, Eliseeva SV.
Biull Eksp Biol Med. 1996 Apr;121(4):407-10. [Carbon dioxide gas inhibition of active forms of oxygen generation by cells in the internal organs and its biological significance] Kogan AKh, Grachev SV, Eliseeva SV.
Fiziol Cheloveka. 1995 Jul-Aug;21(4):128-36. [CO2–a natural inhibitor of the generation of active species of oxygen in phagocytes] Kogan AKh, Manuilov BM, Grachev SV, Bolevich S, Tsypin AB, Daniliak IG.
Patol Fiziol Eksp Ter. 1995 Jul-Sep;(3):34-40. [Comparative study of the effect of carbon dioxide on the generation of active forms of oxygen by leukocytes in health and in bronchial asthma] Kogan AKh, Bolevich S, Daniliak IG.
Can J Anaesth. 1999 Feb;46(2):185-9. Acute respiratory alkalosis associated with low minute ventilation in a patient with severe hypothyroidism. Lee HT, Levine M.Tl128@columbia.edu PURPOSE: Patients with severe hypothyroidism present unique challenges to anesthesiologists and demonstrate much increased perioperative risks. Overall, they display increased sensitivity to anesthetics, higher incidence of perioperative cardiovascular morbidity, increased risks for postoperative ventilatory failure and other physiological derangements. The previously described physiological basis for the increased incidence of postoperative ventilatory failure in hypothyroid patients includes decreased central and peripheral ventilatory responses to hypercarbia and hypoxia, muscle weakness, depressed central respiratory drive, and resultant alveolar hypoventilation. These ventilatory failures are associated most frequently with severe hypoxia and carbon dioxide (CO2) retention. The purpose of this clinical report is to discuss an interesting and unique anesthetic presentation of a patient with severe hypothyroidism. CLINICAL FEATURES: We describe an unique presentation of ventilatory failure in a 58 yr old man with severe hypothyroidism. He had exceedingly low perioperative respiratory rate (3-4 bpm) and minute ventilation volume, and at the same time developed primary acute respiratory alkalosis and associated hypocarbia (P(ET)CO2 approximately 320-22 mmHg). CONCLUSION: Our patient's ventilatory failure was based on unacceptably low minute ventilation and respiratory rate that was unable to sustain adequate oxygenation. His profoundly lowered basal metabolic rate and decreased CO2 production, resulting probably from severe hypothyroidism, may have resulted in development of acute respiratory alkalosis in spite of concurrently diminished minute ventilation.
Anal Bioanal Chem. 2008 Jan;390(2):679-88. Epub 2007 Oct 27. The structural modification of DNA nucleosides by nonenzymatic glycation: an in vitro study based on the reactions of glyoxal and methylglyoxal with 2'-deoxyguanosine. Li Y, Cohenford MA, Dutta U, Dain JA.
Biull Eksp Biol Med. 1995 Jun;119(6):590-3. [Adaptation to high altitude hypoxia facilitates a limitation of lipid peroxidation activation in inflammation and stress] [Article in Russian]Malyshev VV, Vasil'eva LS, Belogorov SB, Nefedova TV.
Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1159-68. Epub 2007 Jun 20.Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Muller FL, Song W, Jang YC, Liu Y, Sabia M, Richardson A, Van Remmen H.
Radiobiologiia. 1984 Jan-Feb;24(1):29-34. [Enzyme activity of glutamic acid metabolism and the Krebs cycle in the brain of rats laser-irradiated against a background of altered adrenoreceptor function] [Article in Russian] Pikulev AT, Dzhugurian NA, Zyrianova TN, Lavrova VM, Mostovnikov VA.
Rejuvenation Res.2007 Dec12; :18072884, Exploring Overlooked Natural Mitochondria-Rejuvenative Intervention: The Puzzle of Bowhead Whales and Naked Mole Rats. Prokopov A.F.
Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences Vol.78, No.10(2002)pp.293-298. DNA methylation and Lamarckian inheritance, Sano H.
Biol Chem. 2009 Nov;390(11):1145-53. The epigenetic bottleneck of neurodegenerative and psychiatric diseases. Sananbenesi F, Fischer A. The orchestrated expression of genes is essential for the development and survival of every organism. In addition to the role of transcription factors, the availability of genes for transcription is controlled by a series of proteins that regulate epigenetic chromatin remodeling. The two most studied epigenetic phenomena are DNA methylation and histone-tail modifications. Although a large body of literature implicates the deregulation of histone acetylation and DNA methylation with the pathogenesis of cancer, recently epigenetic mechanisms have also gained much attention in the neuroscientific community. In fact, a new field of research is rapidly emerging and there is now accumulating evidence that the molecular machinery that regulates histone acetylation and DNA methylation is intimately involved in synaptic plasticity and is essential for learning and memory. Importantly, dysfunction of epigenetic gene expression in the brain might be involved in neurodegenerative and psychiatric diseases. In particular, it was found that inhibition of histone deacetylases attenuates synaptic and neuronal loss in animal models for various neurodegenerative diseases and improves cognitive function. In this article, we will summarize recent data in the novel field of neuroepigenetics and discuss the question why epigenetic strategies are suitable therapeutic approaches for the treatment of brain diseases.
Ukr Biokhim Zh 1994 Jan-Feb;66(1):109-12. [Protective effect of sodium bicarbonate in nitrite ion poisoning]. Shugalei IV, L'vov SN, Baev VI, Tselinskii IV
Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):891-8. Modulation of release of reactive oxygen species by the contracting diaphragm. Stofan DA, Callahan LA, DiMarco AF, Nethery DE, Supinski GS.
Ecology: Vol. 50, No. 3, pp. 492-494. Carbon Dioxide Retention: A Mechanism of Ammonia Tolerance in Mammals. Studier EM and Fresquez AA.
Sci Signal. 2009 Mar 31;2(64): pe17. Reversing DNA methylation: new insights from neuronal activity-induced Gadd45b in adult neurogenesis. Wu H, Sun YE. Neurogenesis in the adult mammalian brain involves activity-dependent expression of genes critical for the proliferation of progenitors and for neuronal maturation. A recent study suggests that the stress response gene Gadd45b (growth arrest and DNA-damage-inducible protein 45 beta) can be transiently induced by neuronal activity and may promote adult neurogenesis through dynamic DNA demethylation of specific gene promoters in adult hippocampus. These results provide evidence supporting the provocative ideas that active DNA demethylation may occur in postmitotic neurons and that DNA methylation-mediated dynamic epigenetic regulation is involved in regulating long-lasting changes in neural plasticity in mammalian brains.
Patol Fiziol Eksp Ter. 2005 Apr-Jun;(2):13-5. [The effect of the NMDA-receptor blocker MK-801 on sensitivity of the respiratory system to carbon dioxide] Tarakanov IA, Dymetska A, Tarasova NN.
Life Sci. 1997;61(5):523-35. Effect of acidotic challenges on local depolarizations evoked by N-methyl-D-aspartate in the rat striatum. Urenjak J, Zilkha E, Gotoh M, Obrenovitch TP. “Hypercapnia reduced NMDA-evoked responses in a concentration-dependent manner, with 7.5 and 15 % CO2 in the breathing mixture reducing the depolarization amplitude to 74 % and 64 % of that of the initial stimuli, respectively. Application of 50 mM NH4+ progressively reduced dialysate pH, and a further acidification was observed when NH4+ was discontinued. Perfusion of NMDA after NH4+ application evoked smaller depolarizations (56 % of the corresponding control, 5 min after NH4+ removal), and this effect persisted for over 1 h.” “Together, these results demonstrate that extracellular acidosis, such as that associated with excessive neuronal activation or ischemia, inhibits NMDA-evoked responses in vivo.”
Arch Int Physiol Biochim. 1977 Apr;85(2):295-304. Glutamate and glutamine in the brain of the neonatal rat during hypercapnia. Van Leuven F, Weyne J, Leusen I.
Pediatrics 1995 Jun;95(6):868-874. Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat. Vannucci RC, Towfighi J, Heitjan DF, Brucklacher RM
Pediatr Res 1997 Jul;42(1):24-29. Effect of carbon dioxide on cerebral metabolism during hypoxia-ischemia in the immature rat. Vannucci RC, Brucklacher RM, Vannucci SJ
Sci. Signal., 31 March 2009 Vol. 2, Issue 64, p. pe17, Reversing DNA Methylation: New Insights from Neuronal Activity-Induced Gadd45b in Adult Neurogenesis Wu H, Sun YI

D:2021.08.30
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